All odds via FanDuel Sportsbook
- Los Angeles Chargers @ New England Patriots: +5.5
- Arizona Cardinals @ Pittsburgh Steelers: -6.5
- Denver Broncos @ Houston Texans: -3.5
- Detroit Lions @ New Orleans Saints: +4.5
- Indianapolis Colts @ Tennessee Titans: +1.5
- Atlanta Falcons @ New York Jets: +1.5
- Miami Dolphins @ Washington Commanders: +9.5
- Carolina Panthers @ Tampa Bay Buccaneers: -5.5
- San Francisco 49ers @ Philadelphia Eagles: +3
- Cleveland Browns @ Los Angeles Rams: -3.5
- Kansas City Chiefs @ Green Bay Packers: +6
- Cincinnati Bengals @ Jacksonville Jaguars: -8.