As we approach fantasy football championships, it's important you know the game has changed. While roster spots are typically among the most valuable assets in fantasy, that's just no longer the case. There just isn't much time left for players to establish themselves. In other words: if you're not starting a player now, you probably won't start them for the rest of the year. This should be reflected in your management style.
You'll want your starters (obviously), a few backups at running back and wide receiver, any streaming options you have planned out, and the rest should be players whose value can change quickly (like handcuff running backs.