Throughout his career, New York Giants quarterback Eli Manning has faced the San Francisco 49ers eight times in the regular season. With a record of 5-3, Manning’s success against the Niners includes a few special performances.
That being said, here are the five best games Manning has had against the 49ers throughout his long career.
5. 2007 Week 7 Home Victory
With a record of 4-2, the Giants hosted the 49ers at The Meadowlands in this Week 7 game. And right off the bat, fans could tell Eli was in for a solid performance.