The (+10) conclude their two-game road trip on a short week against the San Francisco 49ers (-10). New York defeated the Cardinals in dramatic fashion after overcoming a 21-point deficit, and the 49ers are 2-0, averaging 30 points per game. The Giants' comeback vs. Arizona tied for the largest in franchise history.
Star running back Christian McCaffrey currently leads the NFL in rushing. The 49ers are number one in EPA, third in team rushing total, and are +3 in turnover differential. The 49ers’ defense is led by Nick Bosa, who has nine pressures but zero sacks through two weeks.