TEMPE, Ariz. -- New York Giants star running back Saquon Barkley has been ruled out for Thursday night's matchup against the San Francisco 49ers because of an ankle injury.
Barkley suffered the injury late in New York's comeback victory Sunday over the Arizona Cardinals, and a source told ESPN's Adam Schefter this week that the two-time Pro Bowler was expected to miss three weeks.
Barkley was projected with a "did not practice" designation since New York conducted only walk-throughs during the short week, but Giants coach Brian Daboll hinted Tuesday that Barkley might play in San Francisco, calling him a "quick healer.