Daniel Jones and the short-handed Giants were unable to overcome the strongest opponent they have faced since the opener, falling 28-10 to the Vikings at MetLife Stadium on Sunday.
It was the first career loss for the rookie quarterback and ended a two-game winning streak for the Giants (2-3).
Already without starting running back Saquon Barkley, the Giants lost his main replacement, Wayne Gallman, early in the game to a concussion. That left them with only rookie Jon Hilliman and fullback Eli Penny as ball-carriers. Meanwhile on defense, the Giants were missing three of their four starting linebackers due to injury as Lorenzo Carter was ruled out pregame with a neck injury.