The four players that were put on injured are right guard D.J. Fluker (toe), cornerback Donte Deayon (broken forearm), and linebackers Deontae Skinner (hamstring) and Curtis Grant (ACL).
The loss of Fluker really hurts as he helped give the Giants a much-needed boost to their running game in the six games he started.
Fluker was selected in the first round of the 2013 draft by the Chargers, where he played with them until they released in March.
He started 59 games with the Chargers playing both right tackle and right guard.