For the third consecutive week, the Buffalo Bills (-6)
(4-1) will face off against an opponent that handed them a difficult loss over the past two seasons in the Tennessee Titans (+6) (3-2), when they travel to Nashville for Monday Night Football.
Last season, the Titans defeated the Bills, 42-16, while handing Buffalo its first loss. Tennessee is coming off of a 37-19 victory over the Jacksonville Jaguars (+7.5)
in Week 5 and is in first place in the AFC South.
Meanwhile, the Bills will be riding the high of arguably the biggest game of the season so far as they defeated the Kansas City Chiefs (-4.