(8-3) and Carolina Panthers (8-3) know each other well heading to Sunday's game at the Mercedes-Benz Superdome.
But even with the deep familiarity, the Saints have challenges to prepare for in the second meeting of the season between the two NFC South divisional foes.
One of the primary obstacles is Cam Newton, who has returned to being a dual-threat quarterback since the Saints secured a 34-13 win over the Panthers in Week 3.
"I think obviously Cam is running with the football a little bit more than he did the first time that we played them," defensive coordinator Dennis Allen said.