The New Orleans Saints host the Indianapolis Colts in a primetime Monday night affair that will wrap up Week 15. The Saints lost at home last Sunday to the San Francisco 49ers 48-46, despite an explosive offensive performance where they had season-highs in points and first downs (28) while rolling up 465 yards in total offense. New Orleans may need to duplicate that offensive production to make up for a defense that has multiple impactful injuries. The Saints come into this game averaging nearly 27 points per game, fifth best in the league, and 369 yards of total offense to rank twelfth.