Quarterback Drew Brees lost two fumbles and tight end Michael Hoomanawanui had the third. Brees' fumbles were caused by Phildelphia defensive lineman Fletcher Cox, who had three sacks. The Saints were missing starting left tackle Terron Armstead and starting right guard Jahri Evans, who were inactive because of injuries. Brees was intercepted by Walter Thurmond late in the fourth quarter leading to a 4-yard Demarco Murray touchdown run.
The loss dropped the Saints to 1-4. They will host the Atlanta Falcons on Thursday at the Mercedes-Benz Superdome.
Bradford had two touchdown passes (Josh Huff, Brent Celek) to overcome two end-zone interceptions (Brandon Browner, Delvin Breaux) and finished 32 of 45 for 333 yards.