The latest from NFL games around the league on the fourth Sunday of the season (all times EDT):
1:25 p.m.
Top overall draft pick Jameis Winston is off to a tough start, losing a fumble on Tampa Bay's second play against Carolina and having his first pass intercepted and returned for a touchdown.
The fumble — on a snap in the rain — set up a field goal. Josh Norman's interception and 46-yard return up the left sideline gave the Panthers a 10-0 lead.
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1:20 p.m.
New York Giants left tackle Ereck Flowers aggravated an ankle injury on the opening drive and his return is questionable.