The New England Patriots and San Francisco 49ers will each be looking to end a two-game losing streak when they meet Sunday in Santa Clara, Calif. After opening the season with a 16-10 victory at Cincinnati, New England (1-2) dropped a 23-20 decision to Seattle at home in Week 2 before losing to the New York Jets 24-3 on the road in Week 3. The 49ers (1-2) began their season with a 32-19 home victory against the Jets, but they have since suffered losses at Minnesota (23-17) and at the Los Angeles Rams (27-24). In addition to missing running back Christian McCaffrey, who is on injured reserve with Achilles tendinitis, the 49ers were without wide receiver Deebo Samuel (calf) and tight end George Kittle (hamstring) against the Rams.
Struggling on defense, 49ers meet offense-challenged Patriots
