The Patriots already had ruled out running back Damien Harris for Sunday with an ankle injury. On Saturday, they placed Harris on injured reserve.
Harris, 23, began the season on injured reserve before being activated to the 53-man roster on Oct. 5.
He started all 10 games he played this season and had 137 rushing attempts for 691 yards and two touchdowns. He also caught five passes for 52 yards.
The Patriots signed tight end/defensive end Rashod Berry, defensive back Michael Jackson Sr. and linebacker Cassh Maluia to the 53-player roster from the practice squad.