The Patriots will be without DeVante Parker on Sunday after the receiver was ruled out with a head injury.
Offensive tackle Calvin Anderson will also miss the game against the Commanders with an undisclosed illness.
The Commanders will be without receiver Curtis Samuel, who has 35 catches for 332 yards and a pair of touchdowns this season.
The Patriots listed ten players as questionable, including Christian Barmore, Trent Brown, and Ja’Whaun Bentley.
With Parker out and Kendrick Bourne sidelined for the season, there will be opportunities for younger Patriots receivers such as Demario Douglas, Kayshon Boutte, and Jalen Reagor to earn snaps.