The New England Patriots will visit the Denver Broncos short an additional two starters.
The organization downgraded tight end Hunter Henry and offensive tackle Conor McDermott to out prior to traveling on Saturday.
Both veterans had been listed as questionable on the final injury report of Week 16.
Henry, 29, missed consecutive practices before returning as a limited participant on Friday. Standing with 42 receptions for 419 yards and a team-leading six touchdowns on the season, the team captain suffered a knee injury against the Kansas City Chiefs.