With Jimmy Garoppolo starting for the Patriots, Carson Wentz behind center for the Eagles and Shaun Hill or Sam Bradford - who really knows? - throwing passes for Minnesota, the first week of the NFL season will play out Sunday with plenty of uncertainty about what to expect.
Other players expected to be absent in Week 1 include Patriots tight end Rob Gronkowski and Chiefs running back Jamaal Charles, while some are returning from injury, including Green Bay wideout Jordy Nelson and Ravens quarterback Joe Flacco.