Mac Jones threw the first touchdown pass of his career, helping the Patriots forge a 10-10 tie at halftime.
Jones, the 15th overall choice, completed 14 of 19 passes for 133 yards. Nelson Agholor, who was questionable to play, has four catches for 51 yards, including a 7-yard touchdown with 2:30 remaining in the first half.
Jones got plenty of help from Damien Harris, who ran for 72 yards on 11 carries.
Tua Tagovailoa, making his 10th career start after the Dolphins used the fifth overall choice on him last year, had a 3-yard touchdown run.