It was known the San Francisco 49ers' offense would be shorthanded when it faced the New England Patriots in a Week 4 game at SoFi Stadium. Christian McCaffrey was placed on injured reserve, Deebo Samuel is expected to miss a couple weeks and George Kittle missed Week 3 due to hamstring tightness.
The Niners' defense will be without a key cog, too.
Pro Bowl defensive tackle Javon Hargrave is headed for injured reserve after he suffered a triceps injury against the Los Angeles Rams. Hargrave served as an anchor on the defensive front and graded as San Fran's best defensive tackle in passing situations, per Pro Football Focus.