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Injury Report Analysis: Projecting the Patriots Starting Offensive Line and Potential Matchups in the Secondary vs. the 49ers

The Patriots are en route to San Francisco for a matchup with the 49ers, and both teams are managing significant injuries that could impact this Week 4 tilt.

On the Patriots side, New England ruled out CB Alex Austin (ankle), G Michael Jordan (ankle), and OT Vederian Lowe (knee) for Sunday's game. The following players are questionable for the Patriots: LB Anfernee Jennings (shoulder), G Sidy Sow (ankle), CB Jonathan Jones (shoulder), and OT Caedan Wallace (knee).

The concern for New England is the left side of the offensive line. The Patriots are 32nd in pass-block win rate, with QB Jacoby Brissett being pressured on a league-high 46.