When the Patriots last took the field against the Bills in Week 16 of the 2020 NFL season, they marched Cam Newton onto the field as their starting quarterback. Sony Michel served as his top running back while Damiere Byrd and Devin Asiasi were starters at receiver and tight end respectively.
Safe to say that a lot has changed since then.
In fact, when looking at the starting roster that the Patriots fielded against the Bills last season, it is almost completely different. Only six of the 22 combined starters on offense and defense are projected to start for the Patriots in Week 13 against the Bills.