The Patriots are facing one of the better teams in the NFL this week the Cincinnati Bengals. They are the defending AFC champions and narrowly lost the Super Bowl 23-20. Their Offense is ranked #10 and is one of the better units in the league. On Defense, they are ranked #16 giving up 226 passing yards a game while allowing the opposition to run for 100 yards a game. They are well-balanced on offense between the run and pass.
| STARTER | 2ND | 3RD | 4TH | |
| QB | Joe Burrow | Brandon Allen | – | – |
| RB | Joe Mixon | Samaje Perine | Trayveon Williams | Chris Evans |
| WR | Ja’Marr Chase | Trenton Irwin | – | – |
| WR | Tee Higgins | Trent Taylor | – | – |
| WR | Tyler Boyd | Stanley Morgan | – | – |
| TE | Hayden Hurst Q | Mitchell Wilcox | Devin Asiasi | Drew Sample IR |
| LT | Jonah Williams | D’Ante Smith | – | – |
| LG | Cordell Volson | Jackson Carman | – | – |
| C | Ted Karras | Trey Hill | Ben Brown | |
| RG | Alex Cappa | Max Scharping | – | |
| RT | La’el Collins | Hakeem Adeniji |
Quarterback
Joe Burrow has started since he was drafted #1 in 2020.