In today's NFL, the spread offenses from college have become a major part of the game. Then Tom Brady , Kurt Warner , and Peyton Manning bursted onto the scene, winning championships and setting records throwing with 3+ WR formations that took advantage of teams that either put a linebacker or a backup CB on the 3rd WR back in the early 2000s. The NFL is a copycat league, and most teams adapted that to their offenses. To counter that, most teams now will sub in a defensive back for either a linebacker (4-3) or nose tackle (3-4).