Leonard Fournette, the NFL's second-leading rusher, will not play for the Jacksonville Jaguars against the Indianapolis Colts on Sunday.
Fournette did not practice this week with a sprained right ankle, and Chris Ivory starts in Fournette's place.
Fournette has rushed for 596 yards, second to Kansas City's Kareem Hunt (630), and nobody has scored more rushing touchdowns than Fournette's six. His seven overall TDs also are tied for the league high with Los Angeles Chargers running back Melvin Gordon and Los Angeles Rams running back Todd Gurley.
Brandon Linder, the Jags' starting center, was ruled out Friday with an illness.