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3 reasons why Patriots came up short to 49ers

Both the Patriots and 49ers entered Sunday’s matchup at Levi’s Stadium with a banged-up depth chart.

An already laboring New England roster took several hits to their porous offensive line. Vederian Lowe was ruled out for the second straight game, prompting Jerod Mayo to roll with waiver-wire pickup Demontrey Jacobs at left tackle.

A Patriots defense fresh off of giving up 400 yards to the Jets in Week 3 didn’t have its top edge setter in Anfernee Jennings — just a week removed from losing defensive captain Ja’Whaun Bentley for the year due to a torn pectoral muscle.