Southern Miss, playing under the radar this season, emerged as the best bet in college football, going 10-2 against the spread. The Golden Eagles, who won a total of four games over the previous three seasons, look to complete a remarkable turnaround when they take on Western Kentucky in the Conference USA Championship Game on the Hilltoppers' home field in Bowling Green on Saturday afternoon.
Point spread: The Hilltoppers opened as 7.5-point favorites, according to sportsbooks monitored by Odds Shark (line updates and matchup report).
College football pick, via Odds Shark computer: 43.