West Virginia has agreed to separate with athletic director Shane Lyons, who has been at the school since 2015.
A combination of budget issues and the school's struggling football program led to a change in direction. The school has not decided on coach Neal Brown's future, sources told ESPN.
Lyons' departure highlights Brown's uncertain status as he is 21-24 in four seasons and one loss from clinching the program's third losing record in his four years.
Brown toppled Oklahoma to snap WVU's nine-game losing streak to the Sooners, but at 4-6 the Mountaineers remain a long shot to reach a bowl game.