The Ohio State Buckeyes are 4-1 both straight up and against the spread over the last five meetings with the Penn State Nittany Lions, but the Lions shocked the Buckeyes last year on their way to the Big Ten championship.
In a game that might decide a division title Penn State takes on Ohio State on Saturday afternoon at the Horseshoe.
College football point spread: The Buckeyes opened as seven-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 37.