Ohio State owns the recent rivalry with Illinois, winning the last seven meetings straight up, going 5-2 against some large spreads. The Buckeyes will go against another big number when they dance with the Illini Saturday afternoon in Champaign.
Point spread: The Buckeyes opened as 16-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 41.1-23.9 Buckeyes
Why the Ohio State Buckeyes can cover the spread
OSU remained undefeated on the season with a 28-14 victory over Minnesota last week.