Michigan knocked off Penn State last season, but before that, the Nittany Lions had beaten the Wolverines four times in a row, going 4-0 against the spread. Michigan will shoot for a second straight victory in this series and try to stay alive in the Big 10 East when it visits Happy Valley on Saturday afternoon.
Point spread: The Wolverines opened as five-point favorites, according to sportsbooks monitored by Odds Shark (line updates and matchup report).
College football pick, via Odds Shark computer: 32.3-25.3 Wolverines
Why the Michigan Wolverines can cover the spread
Since losing that game to Michigan State in excruciating fashion a month ago, the Wolverines have won three straight, including a thrilling 48-41 overtime decision at Indiana last week.