The Iowa Hawkeyes lead the all-time rivalry with the Iowa State Cyclones 43-22, with three wins in a row. But ISU is 4-3 against the spread over the last seven meetings, pulling three outright upsets and keeping a couple other games close. Which side is the smart bet for Saturday afternoon's battle for the Cy-Hawk Trophy in Iowa City?
College football point spread: The Hawkeyes opened as 3.5-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 18.2-14.8 Hawkeyes (College football picks on every game)
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