Ohio State, as it does with so many of its Big Ten rivals, dominates the series with Indiana, winning the last 23 meetings in a row. However, the Hoosiers are 6-1 against the spread over the last seven meetings, covering as underdogs, and they should have covered last year. Who's the smart bet for Saturday afternoon's border battle at the Horseshoe in Columbus?
College football point spread: The Buckeyes opened as 27.5-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 48.