Penn State saw its CFP hopes fade away with a loss to Michigan State last week, while Oklahoma will need to regroup quickly after a loss in the Red River Shootout put a large dent into its playoff chances. How will the Nittany Lions and Sooners respond to their defeats? Plus, Syracuse looks to get back on track and Washington State tries to shut down Oregon's momentum.
Oklahoma (-7.5) at TCU
Sat. 10/20, 12:00 p.m. ET
Pick: Oklahoma -7.5
Since the start of the 2014 season, Oklahoma is 4-1 both straight up and against the spread when coming off a bye week.