The College Football Playoff kicks off on Friday night from Notre Dame Stadium.
The Notre Dame Fighting Irish will be the first team to host a playoff game as part of the new 12-team format.
Marcus Freeman's team is currently the smallest favorite on the first-round odds board at seven points.
The other point spreads vary between 7.5 and 12 points, a sign that home-field advantage could be a massive advantage in the first round.
The gap in quality of play could be stark across the weekend as well if the games go as the odds suggest.