Back to the NCAA Newsfeed

College Football Odds Week 2: Picks, Spread Predictions for Top 25 Games

Potential is the best word to describe the Week 2 college football schedule.

There's potential for a handful of upsets to occur throughout Saturday, while there's also potential for the top teams in the nation to run rampant and produce eye-popping offensive totals.

Of the top 25 teams facing FBS opposition, eight of them are favored by 20 points or more, and that list doesn't include the ranked programs taking on FCS opponents with no current odds set.

Below is a breakdown of some of the top Week 2 matchups as well as predictions for every game involving a ranked team.