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College Football Betting Odds Week 13: Picks Against the Spread for Top 25 Schedule

The Indiana Hoosiers' potential result against the Ohio State Buckeyes has been the No. 1 topic of discussion in college football circles leading into Week 13.

Indiana enters Columbus with an undefeated record, but its College Football Playoff position could be in peril with a loss.

At minimum, Indiana must keep the game within the point spread to feel like it competed with the second-ranked Buckeyes.

Some would argue that a 10-point loss would not be good enough to save Indiana from falling behind the collection of two-loss SEC teams.

All of the college football focus in Week 13 will be on Ohio Stadium, but there are a few other important clashes that will take place later in the day, especially in the Big 12.