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College Football Betting Odds Week 10: Picks Against the Spread for Top 25 Schedule

Several ranked teams will be in action this weekend, but no game on the college football slate is as highly anticipated as the clash between No. 4 Ohio State and No. 3 Penn State.

That game between Big Ten rivals will have major implications not only for the Big Ten title race, but also for the College Football Playoff.

The only other game featuring Associated Press Top 25 teams going up against each other will see No. 18 Pittsburgh and No. 20 SMU on Saturday night in a battle between teams that are undefeated in ACC play.