Clemson is 3-0 straight up over the last three seasons against rival Florida State, winning those games by an average score of 30-20. But the Seminoles are 2-1 against the spread over that span, keeping a couple of games close as underdogs. Can Clemson cover as a double-digit favorite in Tallahassee on Saturday afternoon? Or is Florida State the play as a home dog?
College football point spread: The Tigers opened as 17-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 38.