The two fought at UFC Fight Night 27 in 2013 and RDA won the bout via unanimous decision.
UFC officials announced the match-up on Thursday morning.
dos Anjos (24-7) dethroned Anthony Pettis at UFC 185, when he beat him from bell to bell. The Brazilian is riding a four-fight winning streak, with victories over Jason High, Benson Henderson, Nate Diaz and the aforementioned Pettis.
Cerrone (28–6, 1NC) has put together an eight-fight winning streak, with three fights in 2015, four in 2014 and one in 2013. This bout will be Cowboy’s fourth appearance inside the Octagon in 2015.