A bantamweight Muay Thai rematch between Sangmanee P.K.Saenchai and Kulabdam Sor.Jor.Piek-U-Thai headlines ONE Friday Fights 2. They met previously in a bantamweight Muay Thai tournament at ONE: No Surrender 3 on July 31, 2020, where Kulabdam won by first-round knockout. The co-main event will be between Chalamkhao P.K.Saenchai and Petchthong Kiatsongrit as they face off in a strawweight Muay Thai bout.
At the weigh-ins, the bantamweight Muay Thai bout between Pongsiri P.K.Saenchai and Ferzan Cicek was moved to a catchweight of 152 pounds due to the pair failed to make weight in the bantamweight division; Thai-Ngan Le weighed in at 119 pounds, 4 pounds over the atomweight limit.