The former UFC heavyweight champion was formally given a two-year suspension from USADA on Tuesday as a result of a failed drug test earlier this year.
Werdum, 41, tested positive for the anabolic steroid trenbolone and its metabolite epitrenbolone in an out-of-competition urine screening conducted on April 25 in advance of his scheduled UFC Moscow fight against Aleksei Oleinik.
Werdum was subsequently removed from the fight following the failed test and replaced by Mark Hunt, who fights Oleinik at UFC Moscow this weekend.
Werdum (23-8-1) is widely considering to be one of the greatest heavyweights of his era.