The top-ranked Villanova Wildcats (14-1) will try to beat the 10th-ranked Xavier Musketeers (15-2) for the ninth time in 10 meetings as big home favorites at the sportsbooks when they square off in a key Big East matchup Wednesday.
The Wildcats have dominated the series with the Musketeers dating back to 2014, winning eight of the last nine both straight up and against the spread.
Point spread: The Wildcats opened as nine-point favorites; the total is at 164, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College basketball betting pick, via OddsShark computer: 81.