The Major League Soccer All-Star side have downed some high-profile European sides in recent years.
They lost 2-1 to Arsenal in 2016 but, before that, beat Chelsea, Bayern Munich and Tottenham Hotspur.
For the 2017 edition of the clash, an MLS All-Star side that includes Kaka, David Villa, Sebastian Giovinco, Michael Bradley and captain Bastian Schweinsteiger will take on La Liga and UEFA Champions League winners Real Madrid at Chicago's Soldier Field on Wednesday.
Read on for viewing and scheduling details, along with a preview of the clash and predictions.