Only one of the four teams left in the Major League Baseball postseason has qualified for the World Series since 2014.
Houston is looking for its second Fall Classic trip in three years, and it holds home-field advantage in the American League Championship Series against the New York Yankees.
A.J. Hinch's side defeated the Yankees at this stage two years ago, and it has the arms capable of silencing the opposing bats.
Houston is favored to win the ALCS, per Caesars, and it sits at -155 (bet $155 to win $100) to take Saturday's Game 1.