Interleague play may have taken away quite a bit of the unfamiliarity between players in the American and National League, but playing in the All-Star Game and winning it is still a feather in the cap for winning players.
The All-Star Game may not have quite the cultural meaning it did when Ted Williams hit a walk-off home run at Briggs Stadium in 1941 or when Pete Rose steamrolled Ray Fosse at Riverfront Stadium in Cincinnati in 1970, but it's still a point of pride for all players.
For those who decry the winning league in the All-Star Game getting home-field advantage in the World Series, consider that prior to former Commissioner Bud Selig's decision to make that happen, home-field advantage was alternated year-to-year between the leagues.