For Mizzou, there will never be a more loathed rival than Kansas.
Unless there’s another Civil War that pits American states against one another for some reason, the animosity towards the Jayhawks will remain in its own stratosphere. The fiery feelings that date back to the 1850’s have been stoked almost every year since, even if the teams haven’t faced each other on the gridiron since 2011 (they’ll play in Columbia next year, though).
The next tier of rivals is muddied with regional foes – MU has lengthy (and memorable) histories with Oklahoma, Nebraska, Kansas State and Iowa State.