The Tigers (7-2) have won four straight including an 82-72 home victory over Wichita State on Sunday.
The Jayhawks (8-1), also winners of four straight, boast a top-10 defense and a top-30 offense, according to KenPom.com.
Both ESPN and KenPom.com give Mizzou about a 12% chance of victory.
Big man Hunter Dickinson (20.1 points per game) will test Mizzou's interior defense.
Mizzou is led by guard Sean East II (16.8 points per game).
Kansas has won the last four meetings, one of which was an exhibition. The last two games were blowout Jayhawks wins, including a 95-67 laugher in Columbia last December.