The Tigers beat the Hornets 82-65 and will be 11-2 entering Southeastern Conference play.
Guard Tamar Bates led Mizzou with 16 points. Forward Trent Pierce, injected into the starting lineup in a schematic tweak from coach Dennis Gates after point guard Anthony Robinson II was held out of the game with an illness, scored 12 points and grabbed eight rebounds.
Point guard Tony Perkins added a dozen of his own, while forward Mark Mitchell enjoyed one of his most efficient nights of the season, shooting 5-6 from the field and 4-5 from the free-throw line to score 14.