MSU clinched the weekend series from the SEC regular-season championships, while moving to 8-1 against Top 10 opponents this season. The Bulldogs have taken each of the last two series from the Gators.
MSU improved to 30-24 overall and 14-15 in league play, while Florida fell to 41-14 and 20-9.
The MSU series win snapped a streak of 19 straight series wins by Florida.
"Great job by our kids," MSU head coach Gary Henderson said. "I want to thank the fans for their support. This was a great series win for our team. We just had a lot of quality at-bats and pitched it well.