Ole Miss took the first set, 25-19, but Florida battled back to win the second set, 25-21. The Gators then won the third set, 25-21 and clinched the match with a 25-15 win in the fourth.
With the victory, the Gators extend their winning streak to 14 matches and remain first in the SEC with a 9-0 record.
Florida moves to 9-0 in conference play for the 20th time under head coach Mary Wise.
The Gators notched a program record 23 blocks as a squad - led by 12 from Taelor Kellum and 11 from Rachael Kramer.